ABSTRACT
COVID-19 is an infectious disease caused by SARS-CoV-2 that has significant potential cardiovascular implications for patients. Here, we describe a patient referred to Namazi Hospital, Shiraz, Iran, whose COVID-19 polymerase chain reaction test result was positive and developed paroxysmal supraventricular tachycardia. Copyright © 2023, Iranian Heart Association. All rights reserved.
ABSTRACT
Background: It has been believed that infants are at a lower risk for the severe symptoms and complications that arise from COVID-19. This report represents details on a newborn with sepsis that has been diagnosed with COVID-19 and, unfortunately, did not survive. Case presentation: The case was a 1-day-old female newborn, admitted to the surgical intensive care unit in Namazee Hospital, Shiraz, Iran, for a bladder exstrophy operation. She gradually started to deteriorate on the fourth day after the surgery, diagnosed with sepsis based on the results of her blood culture. Progressively, her vital signs and blood tests fell within normal ranges after being treated with broad-spectrum antibiotics. Without any fever, the neonate became severely irritable on the 16th day after her birth and hospitalization. Considering lymphopenia, high CRP, and abnormal chest x-ray, pharyngeal swab sampled for COVID 19. The newborn died from multi-organ failure on the 18th day of life. Reverse transcription-polymerase chain reaction (RT-PCR) confirmed the COVID 19 infection in the dead newborn. The parents' pharyngeal sample, however, was negative for COVID 19. Conclusion: Growing awareness of sepsis as a risk factor for the severity of the COVID-19 infection in the neonatal period can be a form of knowledge for physicians to begin early treatment and reduce odds of mortality in this group of patients.
ABSTRACT
Gathered data about SARS-CoV-2 have shown strong evidence in terms of neuroinvasive and neurotropic capacities of the virus to reach and cause eventual damage to the Central Nervous System. The spread of the virus may occur through direct and indirect ways, leading to anosmia and/or ageusia. These signs have been observed in many COVID-19 patients and are then included in the diagnostic criteria for Neuro-COVID-19. The invasion of SARS-CoV-2 into the dorsal vagal complex of the brainstem has a harmful impact on the respiratory rhythm, with even respiratory failure. There is evidence that immune response abnormalities including cytokine storm and neuro-inflammation influence not only the disease severity, but also the occurrence of neurological and neurodegenerative manifestations. Many umbrella zones remain unclear about Neuro-COVID-19, which requires more consideration in its clinical, biological and therapeutic aspects and may open new research perspectives. © 2020 Fguirouche Abir, Louhab Nissrine, Chraa Mohamed, Kissani Najib and Admou Brahim.